Potentiometeric Study of the Transition Metal (II) Ion Complexes with Drug Diazepam[ 7- Chloro-1- Methyl-5-Phenyl-3H-1,4- Benzodiazepine -2- One]

Neeraj Sharma

Biotech Department, G.L.A. Institute of Professional Studies, Mathura (India).

ABSTRACT:

The potentiometer studies have been carried out on metal complexes of Co (II) ; Mn (II) ; Cu (II); & Zn (II) with drug diazepam [ 7- chloro -1- methyl -5- phenyl -3H-1,4- benzodiazepine -2- one ]. The proton ligand dissociation constant of the ligand and the formation constants of their metal complexes have been determined by Albert Serjent method at 25 ± 10C and an ionic strength 0.1 M KNO 3 in 50 : 50 % (v / v) ethanol – water medium. From the variation of pK values with temperature the values of DG, DH and DS were also evaluated in aqueous medium at 25 0C .

KEYWORDS:

Potentiometer; complexes; diazepam

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Copy the following to cite this article: Sharma N. Potentiometeric Study of the Transition Metal (II) Ion Complexes with Drug Diazepam[ 7- Chloro-1- Methyl-5-Phenyl-3H-1,4- Benzodiazepine -2- One]. Orient J Chem 2009;25(2).

Copy the following to cite this URL: Sharma N. Potentiometeric Study of the Transition Metal (II) Ion Complexes with Drug Diazepam[ 7- Chloro-1- Methyl-5-Phenyl-3H-1,4- Benzodiazepine -2- One]. Orient J Chem 2009;25(2). Available from: http://www.orientjchem.org/?p=23259