Synthesis and Biological Evaluation of N3-(4-Substituted Phenyl)-N5-Phenyl-4H-1, 2, 4-Triazole-3,5-Diamine Derivatives

Pawan K. Mishra¹, Rupesh Dudhe², Anshu Chaudhary¹ and P. K. Sharma¹

¹Vishveshwarya Institute of Medical Science Dadri, Gautambudh Nagar - 203 207 (India).

²R. V. Northland Institute of Pharmacy Dadri, Gautambudh Nagar - 203 207 (India).

 

ABSTRACT:

A series of some new  N³-(4-substituted phenyl)-n⁵-phenyl-4h-1, 2, 4-triazole-3,5-diamine derivatives (6a-f) were synthesized from different substituted aniline(1a-f) and tested for antibacterial, antifungal activities against  human pathogenic bacteria and fungi. The structure of the synthesized compounds was elucidated by IR and ¹HNMR spectroscopic techniques. The antibacterial and antifungal screening of the synthesized compound were performed in-vitro by the disc diffusion method.

KEYWORDS:

Triazole; Anti-bacterial; Anti-fungal; disc diffusion

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Copy the following to cite this article: Mishra P. K, Dudhe R, Chaudhary A, Sharma P. K. Synthesis and Biological Evaluation of N3-(4-Substituted Phenyl)-N5-Phenyl-4H-1, 2, 4-Triazole-3,5-Diamine Derivatives. Orient J Chem 2009;25(3).

Copy the following to cite this URL: Mishra P. K, Dudhe R, Chaudhary A, Sharma P. K. Synthesis and Biological Evaluation of N3-(4-Substituted Phenyl)-N5-Phenyl-4H-1, 2, 4-Triazole-3,5-Diamine Derivatives. Orient J Chem 2009;25(3). Available from: http://www.orientjchem.org/?p=23091