Analgesic and Anticonvulsant Activities of 2-Keto-3-(Substituted Aryl)-1-Thiazolidin-4-Ones

Sanidhya Upadhyay, Archana Saxena, R. K. Upadhyay,  Madhu and Grish Babu

Department of Chemistry, N.R.E.C. College, Khurja - 203 131 (India).

ABSTRACT:

Sixteen 2-keto-3-(substituted aryl)-1-thiazolidin-4-ones synthesized by cyclocondensation of ketoazomethine products of five glyoxals with primary amines have been tested for toxicity ; nine products were tested for analgesic activity and eight for anticonvulsant activity. Four non-toxic new products exhibited higher analgesic activity than reference drug morphine whereas only two compounds with high LD50 values found much better in anticonvulsant action than phenytoin used as reference.

KEYWORDS:

2-keto-3-(substituted aryl)-1-thiazolidin-4-ones; analgesic activity; anticonvulsant activity; toxicity; thin-layer chromatography

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Copy the following to cite this article: Upadhyay S, Saxena A, Upadhyay R. K, Madhu M, Babu G. Analgesic and Anticonvulsant Activities of 2-Keto-3-(Substituted Aryl)-1-Thiazolidin-4-Ones. Orient J Chem 2009;25(3).

Copy the following to cite this URL: Upadhyay S, Saxena A, Upadhyay R. K, Madhu M, Babu G. Analgesic and Anticonvulsant Activities of 2-Keto-3-(Substituted Aryl)-1-Thiazolidin-4-Ones. Orient J Chem 2009;25(3). Available from: http://www.orientjchem.org/?p=23089