Synthesis of Novel Thiazolidinone and Acetidinone Derivatives and their Anti Microbial Activity

B. D. Mistry*, K. R. Desai and S. M. Intwala

Department of Cemetery, B. K. M. Scienc, College, Valsad - 396 001 (India).

ABSTRACT:

2’-{2-[(2’’’,6’’’-dichlorophenyl) amino] phenyl}-N-(4-oxo-2-substitutedphenyl (1,3-thiazolidin-3-yl))acetamide 4a-j, 2’-{2""-[2’’’, 6’’’-dichlorophenyl) amino]phenyl}-N-(3-chloro-2-oxo-4-substituted phenylazetidinyl) acetamide 5a-j have been synthesized by the reaction of N-((1E)-1-Aza-2-Substituted phenylvinyl)-2’-{2""-[2’’’, 6’’’-Dichloro Phenyl) Amino] Phenyl} Acetamide 3, with thoglycolic acid,, Chloroacetyl chloride and triethyl amine respectively. The compounds have been screened for their antimicrobial activity against different micro-organisms. The structures of novel synthesized compounds have been established on the basis of elemental analysis, IR, 1H NMR and Mass spectral data."

KEYWORDS:

Thiozolidinone; Azetidinone; Antimicrobial activity

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Copy the following to cite this article: Mistry B. D, Desai K. R, Intwala S. M. Synthesis of Novel Thiazolidinone and Acetidinone Derivatives and their Anti Microbial Activity. Orient J Chem 2009;25(3).

Copy the following to cite this URL: Mistry B. D, Desai K. R, Intwala S. M. Synthesis of Novel Thiazolidinone and Acetidinone Derivatives and their Anti Microbial Activity. Orient J Chem 2009;25(3). Available from: http://www.orientjchem.org/?p=23056