Synthesis, Screening and QSAR Studies of 2,4-Disubstituted 1,5-Benzodiazepine Derivatives

Manish S. Bhatia*, Prafulla B. Choudhari and Kundan B. Ingale    

Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of pharmacy, Near chitranagri, Kolhapur - 416 013 India.

ABSTRACT:

New 2,4-disubstituted 1,5-benzodiazepine derivatives containing different functional groups have been synthesized and screened for their antibacterial activity. The 2,4-disubstituted 1,5-benzodiazepine derivatives were synthesized by reacting substituted chalcones synthesized using aldol condensation with o-phenylenediamine. QSAR studies of synthesized derivatives were performed. QSAR equation show that electronic and liphopholic parameters have good correlation with anti bacterial activity. Lead molecules, which are designed in accordance with QSAR equations, are exhibit improved antibacterial activity.      

KEYWORDS:

1,5-benzodiazepine; QSAR; antibacterial; aldol condensation

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Copy the following to cite this article: Bhatia M. S, Choudhari P. B, Ingale K. B.Synthesis, Screening and QSAR Studies of 2,4-Disubstituted 1,5-Benzodiazepine Derivatives. Orient J Chem 2008;24(1).

Copy the following to cite this URL: Bhatia M. S, Choudhari P. B, Ingale K. B.Synthesis, Screening and QSAR Studies of 2,4-Disubstituted 1,5-Benzodiazepine Derivatives. Orient J Chem 2008;24(1). Available from: http://www.orientjchem.org/?p=23037