Synthesis and Antihistaminic Activity of Chromon [2', 3':6,7] [1,3,4]-Thiadiazepin [2,3-B]-6'- Substituted Quinazolin-4(3H)-Ones
Alok Sharma1, Shailendra Patil2, G. Achaiah3 and Asmita Gajbhiye1
1Department of Pharmaceutical Sciences, Dr. H.S. Gour Vishwavidyalaya Sagar (India) 2Globus College of Pharmacy, Bangarasia, Bhopal (India) 3Medicinal Chemistry Research Lab, University college of Pharmaceutical Sciences, Kakatiya University, Warangal (India)
A series of six title compounds were synthesized and characterized by spectral data. All the compounds were evaluated for in vitro antihistaminic activity by inhibition of isotonic contractions induced by histamine on isolated guinea pig ileum. The activity of chromone[2',3':6,7][1,3,4]thiadiazepine (2,3-b)6’-iodoquinazolin-4(3H)-one (7f) was comparable to that of standard drug pheniramine maleate at the dose of 50 μmol.
KEYWORDS:in vitro Antihistaminic activity; Substituted quinazolin
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| Copy the following to cite this article: Sharma A, Patil S, Achaiah G, Gajbhiye A. Synthesis and Antihistaminic Activity of Chromon [2', 3':6,7] [1,3,4]-Thiadiazepin [2,3-B]-6'- Substituted Quinazolin-4(3H)-Ones. Orient J Chem 2007;23(3). |
| Copy the following to cite this URL: Sharma A, Patil S, Achaiah G, Gajbhiye A. Synthesis and Antihistaminic Activity of Chromon [2', 3':6,7] [1,3,4]-Thiadiazepin [2,3-B]-6'- Substituted Quinazolin-4(3H)-Ones. Orient J Chem 2007;23(3). Available from: http://www.orientjchem.org/?p=20471 |
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