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Synthesis of 1-H-3-(Substituted Phenyl)-5-(Substituted Phenyl)-2-Pyrazoles and Their Derivatives

P. J. Parmar1*, S. I. Rajput2 and A. G. Doshi1

1Department of Chemistry, Vidyabharti Mahavidyalaya, Amravati - 444 602 (India) 2Department of Chemistry, B.P. Arts, S.M.A. Science and K.K.C. Commerce College, Chalisgaon - 424 101 (India) 

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ABSTRACT:

Chalcones(III a-d) were suspended in glacial acetic acid and bromine in acetic acid reagent (25% w/v) to give chalcone disbromides (IVa-c). Chalcones (IIIa-d) or flavones (Va-d) were treated with hydrazine hydrate, aqueous KOH in ethanol to give same pyrazoles (VIa-c) from both methods. Pyrazoles (VIa-d) was reacted with acetic acid to form 1-acetyl pyrazoles (VIIa-d). Pyrazoles (VIa-d) or 1-acetly pyrazoles (VIIa-d) was reacted with acetic anhydride and a pinch of anhydrous sodium acetate to give 1-acetly-3-(2-acetoxy) pyrazoles (VIIe-h) from both methods. Pyrazoles (VIa-d) were condensed with benzoyl chloride in pyridine medium to give 1-benzoyl pyrazoles (VIIi-l).

KEYWORDS:

Synthesis; flavones; pyrazoles derivatives of pyrazoles

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Parmar P. J, Rajput S. I, Doshi A. G. Synthesis of 1-H-3-(Substituted Phenyl)-5-(Substituted Phenyl)-2-Pyrazoles and Their Derivatives. Orient J Chem 2006;22(2).


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Parmar P. J, Rajput S. I, Doshi A. G. Synthesis of 1-H-3-(Substituted Phenyl)-5-(Substituted Phenyl)-2-Pyrazoles and Their Derivatives. Orient J Chem 2006;22(2).Available from: http://www.orientjchem.org/?p=19492



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