Ich Guidance in Practice: Stability Indicating Hplc Assay Method of Venelafaxine in Bulk Form and Solid Dosage Forms
D. Gowri Sankar*, M. Vamsi Krishna and P.V.M. Latha
Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam - 530 003 (India)
A stability indicating high performance liquid chromatographic (HPLC) method was developed for the assay of venelafaxine in bulk form and solid dosage formulations .The HPLC separation was achieved on a lichrospher C-18 column using mobile phase of acetonitrile-phosphate buffer (50:50, v/v, pH 6.8) at a flow rate of 1ml/min and UV detection at 224nm.The method was validated for lineareity, solution stability, accuracy and precision. The detector response for venelafaxine was linear over the selected concentration range from 1-8 μg/ml with a correlation coefficient of 0.9999. Forced degradation studies showed that, the drug was clearly degraded in acidic condition and slightly degraded in basic and neutral conditions. The developed method is simple, accurate, precise and stability indicating. Hence, the method is recommended for routine quality control analysis.
KEYWORDS:Venelafaxine; Stability indicating; HPLC
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| Copy the following to cite this article: Sankar D. G, Krishna M. V, Latha P. V. M. Ich Guidance in Practice: Stability Indicating Hplc Assay Method of Venelafaxine in Bulk Form and Solid Dosage Forms. Orient J Chem 2005;21(3). |
| Copy the following to cite this URL: Sankar D. G, Krishna M. V, Latha P. V. M. Ich Guidance in Practice: Stability Indicating Hplc Assay Method of Venelafaxine in Bulk Form and Solid Dosage Forms. Orient J Chem 2005;21(3). Available from: http://www.orientjchem.org/?p=19291 |
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