ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Synthesis and Biological Assay of Somenew 2,3-Diaryl-5-Methyl-4-Thiazolidinones

Volume 20, Number 1

Anjani Solankee*, Kishor Kapadia, Indrajit Thakor, Jayesh Patel and Smruti Lad

Department of Chemistry, B.K.M. Science College, Valsad- 396 001 (India)

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ABSTRACT:

2-Aryl-3-(4'-trifluoromethylphenyl)-5-methyl-4-thiazolidinones (IIa-IIm) have been prepared by the cyclocondensation of thiolactic acid with schiff bases (Ia-Im) which are prepared by the reaction between 4-amino benzontrifluoride and aromatic aldehydes. The structure of the synthesised compounds have been confirmed by elemental analysis, IR and 1H NMR spectroscopy. All the synthesised compounds are evaluated for their invitro growth inhibitory activity against Gram positive and Gram negative bacteria.

KEYWORDS:

p-Aminobenzotrifluoride; 4-Thiazolidinones; Antibacterial activity

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Solankee A, Kapadia K, Thakor I, Patel J, Lad S. Synthesis and Biological Assay of Somenew 2,3-Diaryl-5-Methyl-4-Thiazolidinones. Orient J Chem 2004;20(1)

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Solankee A, Kapadia K, Thakor I, Patel J, Lad S. Synthesis and Biological Assay of Somenew 2,3-Diaryl-5-Methyl-4-Thiazolidinones. Orient J Chem 2004;20(1) Orient J Chem 2001;20(1). Available from: http://www.orientjchem.org/?p=18395


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