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Synthesis and Antibacterial Activity of 1-Isonicotinyl-3-Methyl-4-(Substituted Phenyl Hydrazono)-2-Pyrazolin-5-one  

Volume 18, Number 2

Mohammed Amir*, S. M. Hasan and A. Wadoo

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard New Delhi-110 062 (India)

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ABSTRACT:

Various 1-isonicotinyl-3-methyl-4-(substituted phenyl hydrazono)-2-pyrazolin-5-one were synthesized and evaluated for their antibacterial activity. The compound showed significant antibacterial activity against Staphylococcus aureus (Gram +ve) and Escherichia coli (Gram -ve) bacteria by agar plate diffusion method.

KEYWORDS:

Pyrazolin-5-one; Antibacterial activity

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Amir M, Hasan S. M, Wadoo A. Synthesis and Antibacterial Activity of 1-Isonicotinyl-3-Methyl-4-(Substituted Phenyl Hydrazono)-2-Pyrazolin-5-one. Orient J Chem 2002;18(2).

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Amir M, Hasan S. M, Wadoo A. Synthesis and Antibacterial Activity of 1-Isonicotinyl-3-Methyl-4-(Substituted Phenyl Hydrazono)-2-Pyrazolin-5-one. Orient J Chem 2002;18(2). Available from: http://www.orientjchem.org/?p=17192

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