Controlled Release of Acetaminophen from CMC-Based Hydrogels

Mohammad Sadeghi¹, Fatemeh Soleimani¹ and Mojgan Yarahmadi²

¹Department of Chemistry, Science Faculty, Islamic Azad University, Arak Branch, Arak (Iran). ²Deaprtment of Enghlish, Faculty of Humanities, Ialamic Azad University, Arak Branch, Arak (Iran).

ABSTRACT:

The purpose of this study was to produce intelligent CMC-based super absorbent polymers (SAP) to be used as pH-sensitive carriers for the controlled delivery of Acetaminophen drug. Acrylamide (AAm) monomer was graft copolymerized onto CMC backbones by a free radical polymerization technique using ammonium persulfate (APS) as initiator and methylene bisacrylamide (MBA) as a cross linker. Hydrogel formation was confirmed by FTIR spectroscopy. Results from scanning electron microscopy (SEM) observation also showed a porous structure with smooth surface morphology of the hydrogel. the drug, Acetaminophen, was successfully loaded into the hydrogels and in vitro release studies were performed in SGF for the initial 150 min, followed by SIF until complete dissolution. The release profiles of Astaminophen from the hydrogel were determined by UV–Vis absorption measurement at lmax 266 nm.

KEYWORDS:

CMC; hydrogel; acrylamide monomer; Acetaminophen; releasing drug

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Copy the following to cite this article: Sadeghi M, Soleimani F, Yarahmadi M. Controlled Release of Acetaminophen from CMC-Based Hydrogels. Orient J Chem 2011;27(3).

Copy the following to cite this URL: Sadeghi M, Soleimani F, Yarahmadi M. Controlled Release of Acetaminophen from CMC-Based Hydrogels. Available from: http://www.orientjchem.org/?p=11732