Preparation, chemical and biological study of acyclovir analogue starting from 6-aminouracil

Fadhil B. Essa, Akram Bazbouz and Suzan AL-Lababidi

Department of Chemistry, University of AL-Baath. Homs (Syria).

ABSTRACT:

6-aminouracil14, dibenzosulphonyl ethyl amine¹¹ have been prepared, as starting materials to be introduced as an alkylating reagent with sodium carbonate as catalyst. Acyclovir analogue15 was prepared for the first time, the expected structure of the final newly acyclovir analogue was determined on the basis of NMR, IR, and mass spectroscopy, with low cost, high selectivity, safe and mild reaction conditions.

KEYWORDS:

Chemical and biological study; acyclovir analogue; 6-aminouracil

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Copy the following to cite this article: Essa F. B, Bazbouz A, AL-Lababidi S. Preparation, chemical and biological study of acyclovir analogue starting from 6-aminouracil. Orient J Chem 2010;26(4).

Copy the following to cite this URL: Essa F. B, Bazbouz A, AL-Lababidi S. Preparation, chemical and biological study of acyclovir analogue starting from 6-aminouracil. Available from: http://www.orientjchem.org/?p=11611